Arbejde PhD and Postdoc Positions: Development of Micro-Nano-Bio Systems for Fast Sepsis Diagnosis Hovedstaden Danmarks Tekniske Universitet - jobtilbud

GÆLDER
stillingsbetegnelse:
PhD and Postdoc Positions: Development of Micro-Nano-Bio Systems for Fast Sepsis Diagnosis

jobbeskrivelse:
DTU Nanotech conducts cross-disciplinary research, where micro- and nanotechnology is applied to a wide range of scientific disciplines, e.g., mechanics, optics, chemistry, medical technologies and biotechnology. The BioLabChip group at DTU Nanotech invites applications for one PhD and one Postdoc fellowship positions to develop advanced micro-nano-bio systems for fast sepsis diagnosis. Background The candidates will work on the SMARTDIAGNOS project, which is a newly-funded EU project under Horizon 2020 framework programme. It involves ten partners (including four companies) from five European countries. Sepsis is a great public health issue not only in EU but also worldwide because of its high incidence, mortality and economic cost. Sepsis diagnosis remains one of the greatest clinical challenges in critical care. We aim at advancing sepsis diagnosis by simplifying the current clinical analysis methods and integrating the numerous steps, including sample preparation, DNA amplification and optical detection, into a single plastic cartridge that will be inserted in an instrument. A number of cutting-edge micro-nano-bio and bio-photonic technologies will be developed. The intended diagnostic tool will enable fast and accurate identification of sepsis-related pathogens as well as their antibiotic resistance profiles, so that effective antimicrobial therapy can be initiated. Responsibilities and tasks The PhD and postdoctoral positions will be filled with the best combination of PhD/postdoctoral candidates. Candidates for both positions should demonstrate excellent communication and language skills, a strong drive to obtain results and the ability to work in a highly cross-disciplinary environment. Candidates for the postdoctoral position are further expected to have a proven track of publishing and the ability to generate, plan and execute new ideas. Preference will be given to candidates with experience in international collaborations and in supervision of students. The main task of position 1 is to cover the physical aspects of the device development, including the chip, the setup and the readout. The work includes: (1) design, fabrication and testing of injection molded plastic chips with micro-optical structures; (2) construction and testing of a setup with temperature control, microfluidic handling and optical readout; (3) automation of setup and data analysis; (4) collaboration with other partners on system integration and evaluation using biological samples. The main task of position 2 is to cover the biological aspects. The work includes: (1) development of new sample concentration method to capture pathogens directly from blood; (2) development of multiplexed PCR for identification of a large-panel of pathogens and the relevant antibiotic resistance profiles; (3) implementation of assays on chip platform; (4) collaboration with other partners on system integration and evaluation using biological samples. Qualifications The successful applicant for Position 1 should have a background (MSc/PhD degree or equivalent) in Applied Physics, Mechanical Engineering or related disciplines, with a strong background in micro and nanofabrication, optical detection, and system design and setup. The ideal candidate has experience in microfluidics and injection moulding as well as the construction, application and automation of lab-on-a-chip systems. The candidate should be self-driven, and have a strong interest to work together with biologists and be part of a multidisciplinary team. The candidate will have a high motivation for research, evidence of solid written and oral communication skills. The successful applicant for Position 2 should have a background (MSc/PhD degree or equivalent) in Molecular Biology or related disciplines, with a strong background in sample preparation and molecular amplification techniques, such as PCR. Experiences with microarray and lab-on-a-chip systems will be considered as an advantage. The candidate sh

Arbejdsgiver Navn: Danmarks Tekniske Universitet

Arbejdsgiver telefonnummer: 45252525

Arbejdsgiver faxnummer: 45881799

Job kort beskrivelse:
Undervisning og forskning på universiteter og højere læreranstalter

land: Danmark

region: Hovedstaden

krævede uddannelse: Ikke angivet

Kilde til jobtilbud: AMS, Offentlige arbejdsformidlinger, Danmark

GÆLDER

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