id: NDg5MzM1OSA3

reference: 4893359

documentId: 4893359

connectionPointId: 7

lastModificationDate: 1539768785930

stillingsbetegnelse:
PhD on Post Translational Modifications of Therapeutic Proteins

jobbeskrivelse:

Applications are invited for a 3-year PhD fellowship on understanding the molecular interactions that produce post translational modifications of secreted proteins and applying that knowledge towards production of pharmaceutical biologics. The project will be carried out at the Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark (DTU) in the CHO cell line engineering and development group under supervision of Dr. Lasse Ebdrup Pedersen.

The mammalian bio-pharmaceutical industry produces therapeutic proteins to treat numerous diseases such as cancer, anemia and haemophilia. The most used mammalian cell factory is the Chinese hamster ovary (CHO) cell. Our group is a world leading CHO research group and we seek to improve our understanding of basic cell biology in the area of protein production and to apply that knowledge to predictably produce high quantity and high quality therapeutic proteins.

Responsibilities and tasks

The candidate will do research in the area of post-translational modifications during protein production. The candidate will employ advanced molecular biology tools and the latest -omic technologies, including genomics, proteomics and data analysis.

Your responsibilities will include:

• Wet lab work on molecular biology, mammalian cell biology and high-throughput screening.
• Computational work on -omic data analysis
• Dissemination of results through scientific publications, patents and conference presentations.
• Supervision of MSc or BSc students.

The PhD study also comprises courses equivalent to 30 ECTS credits and an international secondment of 3-6 months duration.

Qualifications

Candidates should have a master's degree in engineering or a similar degree with an academic level equivalent to the master's degree in engineering. A degree in Molecular biology, Biotechnology or similar is preferred.

The candidate should possess most of the following:

• Ability to work independently, to plan and carry out complicated research tasks, and also to be a part of the large research team;
• Team spirit and excellent collaboration skills
• Proficiency with sterile mammalian cell work and molecular biology techniques
• Computer proficiency. Ideally proficient in python.
• Strong analytical skills and excellent judgment ability
• Excellent communication skills, fluent written and oral English
• Well-organized, efficient, result-oriented, have excellent record keeping abilities.

Approval and Enrolment

The scholarship for the PhD degree is subject to academic approval, and the candidate will be enrolled in one of the general degree programmes at DTU. For information about our enrolment requirements and the general planning of the PhD study programme, please see the DTU PhD Guide. http://www.dtu.dk/english/Education/PhD/Rules/PhDguide

Assessment

The assessment of the applicants will be made by Lasse Ebdrup Pedersen.

We offer

DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility.

Salary and appointment terms

The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union. The period of employment is 3 years.

You can read more about career paths at DTU here. http://www.dtu.dk/english/about/job-and-career/working-at-dtu/career-paths

Workplace will be at DTU Lyngby Campus.

Further information Further information may be obtained from Dr. Lasse Ebdrup Pedersen, laeb (at) biosustain.dtu.dk.

You can read more about DTU Biosustain at http://www.biosustain.dtu.dk. http://www.biosustain.dtu.dk/

Application Please submit your online application no later than 2 November 2018 (local time). Applications must be submitted as one PDF file containing all materials to be given consideration. To apply, please open the link "Apply online", fill out the online application form, and attach all your materials in English in one PDF file. The file must include:

• A letter motivating the application (cover letter)
• Curriculum vitae
• Grade transcripts and BSc/MSc diploma
• Excel sheet with translation of grades to the Danish grading system (see guidelines and Excel spreadsheet here) http://www.dtu.dk/english/Education/phd/Applicant/Pre_acceptance-1-

Candidates may apply prior to ob­tai­ning their master's degree but cannot begin before having received it.

Applications and enclosures received after the deadline will not be considered.

All interested candidates irrespective of age, gender, race, disability, religion or ethnic background are encouraged to apply.

The Novo Nordisk Foundation Center for Biosustainability is an international research center at the Technical University of Denmark primarily funded by a grant from the Novo Nordisk Foundation. The center conducts research in engineering of cell factories and in silico systems biology, with the purpose of developing new processes and technologies that can support a more sustainable bio-based production of valuable chemicals in the future. The center brings together some of the world's leading researchers in the field and possesses the advanced equipment and facilities required for achieving its ambitious research goals. Impact on society by innovation has a high priority and the center collaborates worldwide with biotech companies and chemical industries to facilitate the dissemination and exploitation of its results.

DTU is a technical university providing internationally leading research, education, innovation and scientific advice. Our staff of 6,000 advance science and technology to create innovative solutions that meet the demands of society, and our 11,200 students are being educated to address the technological challenges of the future. DTU is an independent academic university collaborating globally with business, industry, government and public agencies.


numberOfPosts: 1

jobCategoriesCodes_0: http://data.europa.eu/esco/isco/C2310

abstractJV_contact_0: Please apply using one of the specified channels

positionTypeCode: directhire

contractTypeCodes_0: fulltime

Arbejdsgiver Navn: Danmarks Tekniske Universitet

source: DK-STAR