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stillingsbetegnelse:
Postdoc in Comparative Genomics and Omics-driven Eukaryotic Genome Minimization

jobbeskrivelse:

This postdoctoral position offers the unique opportunity to work in a dedicated team of PhD students. The postdoc's main tasks will be: Department of Biotechnology and Biomedicine is a major Danish research and teaching department in the field of systems biology and is involved in a wide range of research activities within its field.

We are seeking an ambitious postdoc with a documented history of scientific excellence to be affiliated with the Eukaryotic Molecular Cell Biology group as well as collaborations into other groups at the department.

The position is funded by a grant from the Independent Research Fund Denmark.

Responsibilities and tasks

Fungi of the genus Aspergillus are of large economic importance due to their widespread application in industry and their natural capabilities as highly efficient cell factories. In particular, the Aspergilli are natural enzyme producers, and preferred hosts for heterologous enzyme production, but some species also play roles in plant, animal, and human pathogenicity. All known species produce a wide range of bioactive compounds. This project is a part of our long-term efforts to whole-genome sequence the entire fungal genus of Aspergillus, more than 350 species, and to utilize this information for both fundamental and applied research, thereby building superior fungal cell factories and fungal products for the future.

This postdoctoral position offers the unique opportunity to:

• Work with high-quality genome sequences for an entire eukaryotic genus and employ them with state-of-the-art genome engineering and editing.
• Be a part of a team of three staff members (one PhD student and a technician), where the goal is to reduce the genome size of an Aspergillus species significantly, thereby both studying the effects of reducing the genome, and following the hypothesis that a leaner genome will generate a superior strain for industrial purposes.
• Be responsible for daily management of the project in collaboration with the PI and co-PIs.
• Co-supervision of one or more PhD students
• Teaching activities under the course portfolio of the Department

Qualifications

Candidates should have a PhD degree or equivalent.

The successful candidate should have experience with several of the following:

• Writing publications for leading journals in the field.
• Fungal molecular biology and genetic engineering based on USER cloning or Gibson assembly.
• Experience with genetic engineering of Aspergillus using CRISPR
• Data analysis from one or more of the following omics techniques such as genomics, transcriptomics, proteomics.
• Management of large datasets.

It would furthermore be advantageous, but not essential, for the candidate to have knowledge of, or experience with the following:

• Supervision of students.
• Programming in Python, R, or Perl.
• Management of multiple projects.
• Robotics for PCR, vector design, or strain construction.

We offer


DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility.

Salary and terms of employment


The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union.

You can read more about career paths at DTU here http://www.dtu.dk/english/about/job-and-career/working-at-dtu/career-paths

The period of employment is 15 months.

Further information Further information may be obtained from Professor Uffe H Mortensen (um (at) bio.dtu.dk).

You can read more about Department of Biotechnology and Biomedicine and the research groups at http://www.bioengineering.dtu.dk http://www.bioengineering.dtu.dk

Application procedure Please submit your online application no later than 6 March 2019.

Applications must be submitted as one PDF file containing all materials to be given consideration. To apply, please open the link "Apply online," fill in the online application form, and attach all your materials in English in one PDF file. The file must include:

• Application (cover letter)
• CV
• Diploma (MSc/PhD)
• List of publications

Applications and enclosures received after the deadline will not be considered.

All interested candidates irrespective of age, gender, disability, race, religion or ethnic background are encouraged to apply.

The Department of Biotechnology and Biomedicine (DTU Bioengineering) addresses challenges of societal and scientific importance within biotechnology, biomedicine, food technology and human health. The department is based on both basic and applied research and employs tools from biochemistry, biophysics, chemistry, cellular biology, immunology, microbial ecology and physiology, bioinformatics and bio-engineering. Research is conducted within three main areas: Microbial ecology and physiology, Industrial biotechnology and cell factories, and Biomedicine and health. The department has extensive collaboration with national and international research units and industries. DTU Bioengineering has approx. 180 employees, of which 2/3 is scientific staff. The department is located at DTU Lyngby Campus.

DTU is a technical university providing internationally leading research, education, innovation and scientific advice. Our staff of 6,000 advance science and technology to create innovative solutions that meet the demands of society, and our 11,200 students are being educated to address the technological challenges of the future. DTU is an independent academic university collaborating globally with business, industry, government and public agencies.


numberOfPosts: 1

jobCategoriesCodes_0: http://data.europa.eu/esco/isco/C2310

abstractJV_contact_0: Please apply using one of the specified channels

positionTypeCode: directhire

contractTypeCodes_0: fulltime

Arbejdsgiver Navn: Danmarks Tekniske Universitet

source: DK-STAR