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reference: 4940343

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stillingsbetegnelse:
Postdoc in Experimental Biology and Informatics of Membrane Transporters

jobbeskrivelse:
We are seeking a highly motivated postdoctoral researcher to join our highly international research center - The Novo Nordisk Foundation for Biosustainability, Technical University of Denmark, and to become part of the Flux Optimization and BioAnalytics section headed by Prof. Douglas B. Kell.

The New Flux Optimisation and BioAnalytics section at DTU Biosustain https://www.biosustain.dtu.dk/research/research-groups/flux-optimisation-and-bioanalytics is working at the interface between computational biology, synthetic biology, metabolic engineering and bio-based products research, and aims to develop and implement innovative technologies to discover and improve bioprocesses.

Responsibilities and tasks
The successful candidate will focus on projects concerning the analysis, understanding, modelling and engineering of solute transporters (both uptake and efflux) pertinent to both biotechnological production and to human health. A key task will be the production of suitable databases. In addition, he/she will closely collaborate with other members, including bench scientists, as appropriate.

Specific tasks:

• Development and exploitation of molecular biology methods (KO and cloned-up versions) for varying transporter gene expression in organisms such as E. coli.
• Performance of transporter uptake experiments to generate data for core facility-based metabolomics analyses.
• Development and exploitation of experimental synbio methods (library construction, transformation analysis) and their application to transporter improvement
• Key role in the development and population of integrated transporter databases, covering several organisms (both prokaryotic and eukaryotic) and including both proteins and small molecules
• Involvement in acquisition, integration and analysis of data from various sources (literature, omics, phenotypic)

Other content of the position, e.g.:

• Interaction with whole-genome modellers
• Interaction with high-throughput analytics groups
• Cooperation with other institutes of DTU including Bio Engineering/Bio Informatics/Compute.

It is expected that the successful candidate will engage in collaborative efforts will become part of a network with other colleagues at DTU working in computational biology.

Qualifications
Candidates should have a PhD degree or equivalent.

Further qualifications:

• Have or be about to obtain a PhD, an excellent scientific track record with good publications in the relevant field.
• The methods of modern synthetic biology, as applied to at least one of E. coli, S. cerevisiae
• Good knowledge of bioinformatics and preferably cheminformatics
• Documented experience to work in collaborative projects

Also desirable

• Candidates will be expected to have suitable programming experience
• Knowledge of modern web-technologies.
• Knowledge of general machine intelligence and analytics (optimisation, machine learning, clustering)
• Interest and experience in modern data visualization
• A knowledge of workflow systems (e.g. KNIME, Galaxy, Taverna)

We offer
DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility.

Salary and terms of employment
The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union.

You can read more about career paths at DTU here. http://www.dtu.dk/english/about/job-and-career/working-at-dtu/career-paths

Period of employment is initially until December 31st, 2020.

Further information
Further information may be obtained from Douglas Kell kelldb1 (at) fastmail.fm

You can read more about the department at http://www.biosustain.dtu.dk http://www.biosustain.dtu.dk

Application procedure
Please submit your online application no later than 15 February 2019 (local time).

To apply, please open the link "Apply online", fill out the online application form. The following must be attached in English:

• Application (cover letter)
• CV
• Diploma (MSc/PhD)
• List of publications

Applications and enclosures received after the deadline will not be considered.

All interested candidates irrespective of age, gender, disability, race, religion or ethnic background are encouraged to apply.

DTU Biosustain is an international research center of excellence developing next generation cell factories and bioprocesses for sustainable production of high-value chemical compounds as well as protein-based products. The center uses advanced metabolic engineering techniques and computational biology ensuring efficient and cost-effective design and construction processes. The center's activities are a balanced mix of basic and translational research, complemented by an emphasis on business development to facilitate commercialization of new cell factories and associated technologies. DTU Biosustain offers state-of-the-art research facilities and assembles world leaders in the field thus offering a unique platform providing excellent talent development and career opportunities.

DTU is a technical university providing internationally leading research, education, innovation and scientific advice. Our staff of 6,000 advance science and technology to create innovative solutions that meet the demands of society, and our 11,200 students are being educated to address the technological challenges of the future. DTU is an independent academic university collaborating globally with business, industry, government and public agencies.



numberOfPosts: 1

jobCategoriesCodes_0: http://data.europa.eu/esco/isco/C2310

abstractJV_contact_0: Please apply using one of the specified channels

positionTypeCode: directhire

contractTypeCodes_0: fulltime

Arbejdsgiver Navn: Danmarks Tekniske Universitet

source: DK-STAR