stillingsbetegnelse: Professor in Phenotype Selection and Stability

jobbeskrivelse:
The Novo Nordisk Foundation Center for Biosustainability (DTU Biosustain)) at the Technical University of Denmark invites applications for a position as professor to lead the Phenotype and Stability Group. The scientific focus is on development and implementation of new approaches and technologies for accelerating cell factory development and stabilizing favorable production phenotypes. DTU Biosustain is a research center with the overall mission of contributing to research, development and innovation within the following scientific areas: •Discovery of novel biosynthesis routes and exploration of compounds suitable for a sustainable bioproduction •Reduce the costs and time of designing and manufacturing industrially oriented cell factories. The Phenotype Selection and Stability Group at DTU Biosustain currently consist of 18-20 researchers. The group develops synthetic networks that sense intracellular metabolites and control cellular processes. These systems are deployed to discover novel genes and pathways as well as to optimize cell factories for increased chemical production. The work has been focused on developing proof-of-concept for these principles; however, the technology will gradually be deployed towards the development of commercially relevant cell factories. In addition to this work the group conduct genome wide studies on the factors influencing phenotypic stability in E. coli with special emphasize on understanding the pathways by which cells expressing heterologous pathways or specific enzymatic activities can destabilize high yielding production phenotypes in order to construct more robust production strains. Responsibilities and tasks The research shall cover one or more of the areas indicated below: •Application of synthetic selection systems for genome wide screens of novel microbial phenotypes •Development of genome engineering approaches for generation of combinatorial genome wide libraries. •Microbial processing of and tolerance towards microbial inhibitors with a focus on antibiotics and chemical value products •Evolution of tolerance phenotypes including understanding of cross sensitivity and resistance in shaping tolerance evolution. •Functional metagenomics for discovery of new microbial phenotypes, including transporters and resistance/tolerance genes The position covers research, innovation activities, publication and scientific dissemination: •Research - including the obligation regarding publication/scientific dissemination •Developing and managing the Phenotype and Stability including scientific guidance and mentoring of group members •Secure execution of technical and scientific progress of the group in accordance with the overall vision/goals of DTU Biosustain •Integration of group activities with the activities of other DTU Biosustain scientific sections •Facilitation of technology transfer and spin-off activities •Participate in training of entrepreneurial postdocs and PhD students working on scientific and translational research projects. The successful candidate will be responsible for supervising PhD students and is expected to be involved in some other teaching activities related to bachelor and master level students. •Facilitate collaborations with colleagues internally at DTU Biosustain and at other DTU department’s e.g., in terms of joined research proposals, sharing of research infrastructures/technologies, and supervision of students. Qualifications The qualification requirements correspond with those for ordinary professorships within the positions main tasks. The qualification requirements are: •Research at a high international level including significant publication track record •Industrial experience relevant to synthetic and systems biology •Experience in managing a research group spanning from molecular biology to phenotyping •Experience in cutting edge methods in synthetic and systems biology including genome engineering, next generation

Arbejdsgiver Navn: Danmarks Tekniske Universitet

Arbejdsgiver telefonnummer: 45252525

Arbejdsgiver faxnummer: 45881799

Job kort beskrivelse:
Undervisning og forskning på universiteter og højere læreranstalter

land: Danmark

region: Hovedstaden

Kontrakt varighed: Fast

Kontrakttype: Fuldtid

krævede uddannelse: Ikke angivet

Kilde til jobtilbud: AMS, Offentlige arbejdsformidlinger, Danmark