stillingsbetegnelse: Research Scientist in Global Research

jobbeskrivelse:
- Research Scientist - Denmark - Måløv In this job, you will develop and optimise synthesis protocols of future clinical candidates to assure smooth process transfer and secure proper delivery from Discovery to Chemistry, Manufacturing and Controls (CMC). If hands-on organic chemistry and peptide synthesis are your main interests you might be our next chemist in the Transfer Chemistry department within Peptide and Protein Chemistry in the Global Research Unit. The Global Research Unit specialises in the discovery of biological medicines for the treatment of type 1 and 2 diabetes. We also discover and develop new innovative biopharmaceuticals for haemophilia and growth disorders. Furthermore, we conduct stem cell and beta cell regeneration research and other early-stage investigations aimed at finding a cure for diabetes, as well as exploring novel treatments for obesity and long-term, micro-vascular complications of diabetes. The Global Research Unit consists of approximately 1500 highly qualified Scientists, PhDs/PostDocs and Laboratory Technicians and we conduct our world class research from sites based in the Greater Copenhagen area, Beijing, Seattle and Indianapolis. About the department Peptide and Protein Chemistry is a function area within Protein Engineering with the responsibility of engineering peptides and proteins in order to improve the therapeutic properties and to develop early process protocols suitable for Active Pharmaceutical Ingredient (API) upscaling. Our projects embrace not only innovative products for injection, but also ground-breaking oral administration of insulin and GLP-1 analogues. Peptide and Protein Chemistry consist of five departments with about 80 employees of which half holds a PhD degree in chemistry. You will work closely together with nine scientists and technicians in the Transfer Chemistry department. The position The overall objective and primary responsibility of this position is to develop scalable and robust synthetic and semi-recombinant protocols for protein and peptide APIs. Another key responsibility is to develop methods for up-scaling and isolation of agents used for derivatisation of peptides and proteins. The job will cover development and optimisation of solid and solution phase peptide chemistry protocols, development of derivatisation chemistry and semi-recombinant processes in laboratory scale, design and synthesis of building blocks and intermediates, enzymatic mediated modifications as well as development of gram scale purification and isolation technologies. The success of the job depends on the ability to work together with the chemists in Chemistry, Manufacturing and Controls (CMC) to whom you will transfer the optimised protocols aligned to the methods that are qualified for pre-clinical and clinical production of Active Pharmaceutical Ingredient (API). Qualifications You have a strong scientific background and hold a PhD in organic chemistry. If you also have experience with either protein modifications or chemical methodologies within peptide synthesis it would be an advantage. In addition, you have a good knowledge within scientific areas related to drug discovery and development. Experience with preparative purification methods is also required as well as knowledge of analysis and characterisation of proteins and peptides (e.g. High Pressure Liquid Chromatography:HPLC, HPLC-MS and NMR). You are also very interested in expanding your own competences towards protein and peptide technologies such as protein/peptide analysis, characterisation and handling as this is also essential for the job. In addition to your scientific profile you are a positive, open minded and ambitious person with a sound humour and good collaboration skills. Working at Novo Nordisk We always strive for excellence and continuously develop our expertise to stay ahead – both as a company and as individuals. And we believe innovation and creativity thrive in a healthy and engagi

Arbejdsgiver Navn: Novo Nordisk A/S

Arbejdsgiver telefonnummer: 44448888

Arbejdsgiver faxnummer: 44442314

Job kort beskrivelse: Farmaceutarbejde

land: Danmark

region: Hovedstaden

Kontrakt varighed: Fast

Kontrakttype: Fuldtid

krævede uddannelse: Ikke angivet

Kilde til jobtilbud: AMS, Offentlige arbejdsformidlinger, Danmark