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stillingsbetegnelse: Postdoc in Computational structural biology

jobbeskrivelse:
One or two postdoctoral positions are available from Sept 1, 2019, or as soon as possible thereafter, in the Lindorff-Larsen group, Department of Biology, Faculty of Science, University of Copenhagen, Denmark. The postdoctoral fellows will work on a project called BRAINSTRUC within the area of computational aspects of integrative structural biology. BRAINSTRUC is a collaboration between six research groups within structural biology spanning a range of techniques and biological topics, and the successful candidate(s) will be part of a strong and interdisciplinary group of scientists working on developing and applying methods to study the structure and dynamics of proteins.

About BRAINSTRUC and the research environment

The successful candidates will work on computational approaches in integrative structural biology. The project is part of a large interdisciplinary effort called BRAINSTRUC (www.brainstruc.ku.dk) funded by the Lundbeck Foundation. In addition to the Lindorff-Larsen group, the project also involves groups devoted to experimental biophysics and structural biology including X-ray crystallography, CryoEM, NMR, SAXS and SANS. The biological focus within BRAINSTRUC is on protein molecules and complexes in the human brain including membrane transporters, the immune system and protein aggregation. The postdoctoral fellow will use molecular simulations and modelling to study these systems in collaboration with the experimental groups within BRAINSTRUC (for more details including the other partners see www.brainstruc.ku.dk).

We offer a highly dynamic and international research environment located at the Biocenter in central Copenhagen, Denmark (www.bio.ku.dk). The Lindorff-Larsen group combines computational and experimental methods to study the structure, function and dynamics of biomacromolecules. Research within the group covers a broad range of areas in protein science including understanding the relationship between protein dynamics and function, protein design, protein folding and stability, drug resistance, and determining the structures of proteins by integrating experiments and simulations. We also use and develop biophysical methods to interpret genomic sequence variation.

The group is part of the Linderstrøm-Lang Centre for Protein Science at the Department of Biology. The research at the centre is highly interdisciplinary ranging from molecular cell biology to protein chemistry, advanced biophysics and computational biology. The centre also has access to state of the art experimental and computational facilities.

Details of the positions and research topics

The postdoctoral fellows will work on one or more of the subprojects within BRAINSTRUC, focusing on computational methods, both existing and newly developed, together with experimental data to determine the structure and dynamics of complex biomolecules and their assemblies. Experimental data may include NMR, X-ray diffraction, SAXS, SANS, EPR, Cryo-EM and other sources of structural information. For an introduction to the research topic see e.g. our recent review (Bottaro et al, Science, 2018, http://dx.doi.org/10.1126/science.aat4010). The positions are for a period of 2 years.

Research topics for the fellowships include:

• Developing our Bayesian/Maximum Entropy approaches to integrate experiments and simulations
• Using coarse-grained and all-atom simulations to study large molecular complexes
• Using molecular simulations to interpret cryoEM data and experiments
• Integrative methods to study intrinsically disordered proteins

Qualifications

We are seeking motivated and strong applicants with a PhD degree in biophysics, physics, chemistry or biochemistry or similar fields with documented (via peer publications and preprints) prior research experience within one or more of these areas:

• All-atom of coarse-grained molecular dynamics simulations of proteins
• Interpreting structural data using molecular dynamics simulations
• Developing and applying methods for enhanced sampling simulations of biomolecules

It will also be advantageous to have experience with one or more of the following topics:

• Familiarity with interpreting cryoEM data
• Using or developing methods for restraining of reweighting molecular simulations by experimental data

For further information about the positions, please contact Professor Kresten Lindorff-Larsen (lindorff (at) bio.ku.dk). Further information about the Department may be found at https://www1.bio.ku.dk/english/

The position is open from 1st September 2019 or as soon as possible thereafter.

The University wishes our staff to reflect the diversity of society and thus welcomes applications from all qualified candidates regardless of personal background.

Terms of employment

The position is covered by the Memorandum on Job Structure for Academic Staff.

Terms of appointment and payment accord to the agreement between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State.

The starting salary is currently up to DKK 430.569 including annual supplement (+ pension up to DKK 73.627). Negotiation for salary supplement is possible.

The application, in English, must be submitted electronically by clicking APPLY NOW below.

Please include

• A cover letter (max 1. page) explaining your background, key skills and how they are relevant to the research in BRAINSTRUC, and your motivation for applying
• Curriculum vitae (max 2. pages) including educational background previous research experience
• List of publications (including preprints and papers in review)
• PhD diploma including any written evaluation if applicable. If you are expecting to defend your PhD before September 1st and would like to apply, please submit a letter from your supervisor regarding your expected defence date
• Contact details for two former employers or supervisors (no reference letters should be attached)

The deadline for applications is 19th July 2019 23:59 GMT +2.

After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the Interview Committee.

You can read about the recruitment process at http://employment.ku.dk/faculty/recruitment-process/.

Interviews will be held in August 2019.



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Arbejdsgiver Navn: KU - SCIENCE - NBI

source: DK-STAR