stillingsbetegnelse: STAR PostDoc

jobbeskrivelse:
- Research & Development - Denmark - Måløv Our growth is your opportunity Being part of Novo Nordisk Research & Development means working at one of the world's largest and most successful biopharmaceutical companies. Our R&D organisation is vital to Novo Nordisk's continued growth and we always welcome talented people who would like to grow with us. Are you interested in data-driven mathematical models as part of translational research? Are you ready to help us find new GLP-1 analogues which will make a difference to the lives of millions? Do you want to contribute and share your new ideas in an engaging working environment? About the department The Receptor Pharmacology team is part of the Incretin and Islet Biology department and based in the Diabetes Research Unit. The department focuses on in vitro pharmacology and biology related to our incretin-based therapy. The department functions in close collaboration with departments responsible for in vivo biology covering both experimental and computational research. The job One of the main challenges in pharmacology is a poor understanding of the link between in vitro and in vivo data. Most available assays address only ‘acute’ cellular response and a better understanding of a long time scale response is needed to predict the effect of drug candidates in patients. The focus of this 2 year PostDoc project will be to develop a mathematical model describing long time functional response to GLP-1 analogue stimulation in beta-cells. The model will be based on in-house and published experimental data. If needed, additional experiments will be performed by in-house experts to support the model development. Simulated long term functional response will be used to understand and predict in vivo data. Thus, you will have an opportunity to improve the link between in vitro and in vivo data – a necessary step to design drugs greatly improving conditions of patients with diabetes. You will work in a cross-organizational group consisting of experts in GLP-1R in vitro and in vivo pharmacology, both experimentalists and mathematicians. This will ensure idea sharing/brainstorming and your visibility in the organization with the possibility of pursuing further career opportunities in Novo Nordisk. To ensure the state-of-the-art level of the work the project will be carried out in collaboration with Prof. Susanne Ditlevsen at Copenhagen University (Denmark) and Prof. Boris Kholodenko at UCD Conway Institute (Ireland) – world class experts in mathematical modelling of physiological systems using the systems biology approach. The project is expected to generate publishable data to be presented by you at international scientific conferences. Qualifications You have a PhD or similar degree/experience in systems biology, computer science or a related discipline. You have strong computational skills with focus on mathematical modelling of mechanisms behind cellular processes. Examples could be receptor activation and signalling, functional response in primary cells, metabolism etc. Preferably, you are also familiar with modelling of PK/PD data. You should not only be able to develop your models but also to validate them in an experimental context. You are good at communicating with experimentalists in order to ensure the practical application of the model. Knowledge of G-protein coupled receptors (GPCRs) is an advantage but not a must. This position is designated to attract talented researchers (both foreign and Danish) from abroad to Denmark. At Novo Nordisk, we create value by putting patients first. Every ten seconds two people are diagnosed with diabetes, and more than 371 million people worldwide need us. Working here is not just a way to make a living, but a way to make a difference. Contact For further information about the job please contact Nikolaj Kulahin at +45 3075 3829. Deadline 1 December 2014.

Arbejdsgiver Navn: Novo Nordisk A/S

Arbejdsgiver telefonnummer: 44448888

Arbejdsgiver faxnummer: 44442314

Job kort beskrivelse:
Arbejde inden for biologi, botanik, zoologi og beslægtede områder

land: Danmark

region: Hovedstaden

Kontrakt varighed: Fast

Kontrakttype: Fuldtid

krævede uddannelse: Ikke angivet

Kilde til jobtilbud: AMS, Offentlige arbejdsformidlinger, Danmark