Arbejde PhD Fellowship in the Fields of Natural Product Drug Discovery and Protein Research Syddanmark University of Southern Denmark - jobtilbud

GÆLDER
stillingsbetegnelse:
PhD Fellowship in the Fields of Natural Product Drug Discovery and Protein Research

jobbeskrivelse:
A PhD fellowship in the fields of natural product drug discovery and protein research is available at the Department of Chemical Engineering, Biotechnology and Environmental Technology, University of Southern Denmark. The position is available starting 15th of February 2016 or as soon as possible thereafter. The project is performed in collaboration with Prof. Ronald J Quinn, the Eskitis Institute for Drug Discovery, Griffith University, Australia. Approximately two years of the PhD project will be carried out at University of Southern Denmark and one year at Griffith University. Mutations in the TGFBI gene encoding the protein TGFBIp are associated with inherited corneal diseases leading to impaired vision. The diseases include various types of lattice corneal dystrophies (LCDs) and granular corneal dystrophies (GCDs) characterized by corneal deposition of TGFBIp amyloid fibers and granular non-amyloid TGFBIp aggregates, respectively. Studies have shown that mutations leading to LCDs destabilize the TGFBIp protein structure while mutations giving rise to GCDs stabilize the TGFBIp protein compared to the wild-type TGFBIp protein. At present no drugs are available for treatments of these visual conditions. The aim of the PhD project is to identify natural products which will structurally stabilize or destabilize mutant TGFBIp domains and, therefore, have the potential to become drugs for the treatment of TGFBI-linked corneal dystrophies. The PhD project will involve: • Heterologous production of proteins • Purification of heterologous TGFBIp domains • Screening of a natural product library to identify compounds binding the mutant TGFBIp domains • Characterization of complexes between the identified natural products and the TGFBIp domains using different assays. The starting date is 15th of February 2016 or as soon as possible thereafter. Qualification requirements: The applicant must have a Master degree in Engineering or Science within biotechnology, biochemistry or a related topic. Candidates with competences in protein expression, purification and refolding are preferred. In addition, experience with purification and characterization of natural products/small organic compounds and mass spectrometry will be advantageous. The candidate is expected to be highly motivated, reliable and should have excellent written and oral communication skills in English. For more detailed information about the project, please contact Associate Professor Henrik Karring at phone (+45) 6550 9513 or email: hka (at) kbm.sdu.dk. Application, salary and conditions of employment etc. A PhD Fellowship is a three-year salaried position. Enrollment and employment ends automatically by the end of the period. The holder of the fellowship is not allowed to have other paid employment during the three-year period. Employment is governed by the Protocol on PhD Research Fellows signed by the Danish Ministry of Finance and AC (the Danish Confederation of Professional Associations), Cirkulære om overenskomst for Akademikere i staten 2013 and changes to the Agreement with effect from 1 August 2014 Circular is attached here. The faculty expects the applicants to have read the information on work and salary conditions before applying. Applications must be submitted electronically using the link below. Attached files must be in Adobe PDF or Word format. The Faculty expects applicants to read the information “How to apply” before applying. Each box can only contain a single file of max. 10 Mb. An application must include: Completed application form for 5+3 applicants A curriculum vitae A letter stating your interest, motivation etc. Please attach the motivational letter to "application material" under " Research plan" References Verified copies of bachelor diploma and transcript Verified copies of master’s diploma and transcript Calculation of point grade average Please note the definition of verified: Verified official transcripts o

Arbejdsgiver Navn: University of Southern Denmark

Arbejdsgiver telefonnummer: 65501050

Job kort beskrivelse:
Undervisning og forskning på universiteter og højere læreranstalter

land: Danmark

region: Syddanmark

Kontrakt varighed: Fast

Kontrakttype: Fuldtid

krævede uddannelse: Ikke angivet

Kilde til jobtilbud: AMS, Offentlige arbejdsformidlinger, Danmark

GÆLDER

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