stillingsbetegnelse:
PhD position in Structural Biology within the EU ITN project PIPPI - Novozymes (ESR1)

jobbeskrivelse:
A 3-year PhD scholarship in structural biology is available at Novozymes A/S and Department of Chemistry, Technical University of Denmark. The position will be available from 1st of June 2016 or as soon as possible thereafter. The PhD student will be part of the EU-funded project “Protein-excipient Interactions and Protein-Protein Interactions in formulations” (PIPPI). Apart from the research work itself, the students’ participation in the project will involve tight collaboration with project partners and frequent visits to the involved labs, active participation at the bi-annual network events, as well as training in complementary skills such as project management. About PIPPI PIPPI is an Innovative Training Network (ITN) concerning the challenges in formulation of protein-based drugs. PIPPI will combine systematic investigations of the physicochemical behavior of a number of proteins with an in-depth understanding of the molecular interactions behind the macroscopic behavior. The overall objective is to develop methodologies, tools and databases to guide the formulation of robust biopharmaceuticals in the future. The Technical University of Denmark (DK) coordinates this exciting collaborative project. The academic partners include University of Manchester (UK), Ludwig-Maximilian University, Munich (DE), Lund University (SE), University of Copenhagen (DK), MAXIV Laboratory (SE). The industry partners involved in the project include: Novozymes A/S (DK), MedImmune Ltd. (UK), Wyatt Technology Europe GmbH (DE), NanoTemper Technologies GmbH (DE). Each of the project partners contributes world-class competence in particular areas. The core research contribution of DTU Chemistry is in the area of Structural and Computational Biology and comprises X-ray scattering and computer modeling techniques to study structure-function relationship of proteins and protein-protein complexes. The core research contribution from Novozymes is in the area of protein stability and aggregation, protein formulation and protein purification. Protein flexibility and disorder are affected by the physicochemical conditions, and solving and understanding the solution structure under these conditions is the first step towards controlling their behaviour. This PhD project (ESR1) focuses on determination of structure of single domain proteins. The impact of various excipients on the structure will be analysed to find conditions leading to a mono disperse protein solution. The monodispersity of the samples will be ensured by using techniques such as dynamic and static light scattering and asymmetrical flow field flow fractionation-multi angle light scattering and the solution structure will be determined using Small-angle X-ray Scattering. If single crystals are obtained of protein-excipient complexes X-ray crystal structure determination will be used to identify and characterize the molecular interactions. Secondment The successful candidate will visit both academic and industrial partners during the project. This will ensure the buildup of a portfolio of interdisciplinary techniques relevant for the applicant’s project and PIPPI objectives. Qualifications Applicants should hold a Master of Science degree in Chemistry, Biochemistry, Biotechnology, pharmaceutical science, chemical engineering or an equivalent background that provides a strong set of analytical skills. The applicant should have a strong interest in working in a cross-disciplinary environment and should have very good collaboration skills. Strong communication skills and a strong academic record is an advantage. Fluent communication skills in written and spoken English are essential. The applicant should strive towards scientific excellence, be ambitious and hard working. Only applicants with great talent, which seeks to be among the brightest in their field, will be considered. Approval and Enrolment The scholarships for the PhD degree are subject to academic approval, and the candidates

Arbejdsgiver Navn: Danmarks Tekniske Universitet

Arbejdsgiver telefonnummer: 45252525

Arbejdsgiver faxnummer: 45881799

Job kort beskrivelse:
Undervisning og forskning på universiteter og højere læreranstalter

land: Danmark

region: Hovedstaden

krævede uddannelse: Ikke angivet

Kilde til jobtilbud: AMS, Offentlige arbejdsformidlinger, Danmark