stillingsbetegnelse: Two PhD Scholarships in CHO Systems Biotechnology

jobbeskrivelse:
As part of the European Commission funded Marie Sklodowska-Curie Innovative training network (ITN) programme: Enhancing Chinese hamster ovary cells by Mammalian Systems Biotechnology (eCHO-Systems), we are seeking two highly ambitious and talented PhD students to work on interdisciplinary projects at the Novo Nordisk Foundation Center for Biosustainability (DTU Biosustain) in Denmark. eCHO systems is a large Horizon2020 funded programme which brings together fifteen leading academic and industrial partners in an European network, implementing interdisciplinary and intersectorial research and training programme within CHO systems biology, bioprocessing, synthetic biology and genome engineering. The eCHO Systems programme will employ existing and new omics data to transform the CHO cell factory based biopharmaceutical production platform by employing state-of-the-art cellular modeling to integrate, interpret, and apply omics-knowledge and develop synthetic biology and genome engineering tools for CHO. Furthermore, the programme aims to train a new generation of scientists with excellent research, business, innovation and entrepreneurial skills to create the CHO production platforms of the future next-generation of biotherapeutics and biosimilars and to become leaders in small and large private companies and academia. All students in this program will work closely with industrial partners to ensure that knowledge of these advanced systems and synthetic biology concepts will be available to the commercial biotechnology industry. The two PhD students at DTU Biosustain will work close together with two PhD students at DTU Biosustain and 11 PhD students at other academic and industrial sites in Europe that are participating in the ITN programme. Further details on the programme and the positions are available from http://www.echo-systems.eu Job descriptions ESR position 6: Genome editing tools and target identification Objectives: Analysis of genome editing capacity of CHO cells. Development of CRISPR/Cas9 genome editing tools for CHO cells. Development of a flexible donor DNA construction platform for targeted integration. Identification of potential cell line engineering targets. The position includes a secondment to Austrian Center of Industrial Biotechnology (http://www.acib.at). The PhD student will mainly be supervised by Co-Principal Investigator Helene Faustrup Kildegaard. ESR position 11: Engineering nutrient and by-product metabolism Objectives: Identification of unwanted metabolic pathways and by-products using omics data. Survey of nutrient metabolism and specific rates for uptake and formation. Application of published models and draft models for generation of cell lines with reduced by-product formation. Engineering of cell lines with improved nutrient metabolism. The position includes a secondment to CMC Biologics (http://www.cmcbio.com). The PhD student will mainly be supervised by Associate Professor Mikael R. Andersen. Qualifications Mandatory requirements: •Master degree in biology, biochemistry, biotechnology or bioengineering or a similar degree with an academic level equivalent to the master’s degree •Strong work ethic and motivation to succeed within a competitive research field •Good communication skills in English, both spoken and written •Good analytical skills and the ability to work both independently and as part of a team •A strong motivation to work in a trans-European network at the interface of industry and academia Preference is given to candidates with experience in: •Mammalian cell cultivation •Systems biology and omics-based technologies •Molecular biology and cell biology •Biotechnology and biochemistry •Bioprocessing Conditions As a Marie Curie Early stage-researcher, you shall at the time of recruitment be in the first four years (full-time equivalent research experience) of your research career and have not yet been awarded a doctoral degree. At the time of recruitment, yo

Arbejdsgiver Navn: Danmarks Tekniske Universitet

Arbejdsgiver telefonnummer: 45252525

Arbejdsgiver faxnummer: 45881799

Job kort beskrivelse:
Undervisning og forskning på universiteter og højere læreranstalter

land: Danmark

region: Hovedstaden

krævede uddannelse: Ikke angivet

Kilde til jobtilbud: AMS, Offentlige arbejdsformidlinger, Danmark